Infection with the rational use of antibiotics.docVIP

 PAGE \* MERGEFORMAT 8 Infection with the rational use of antibiotics [Keywords:] nosocomial infection Keywords:: Nosocomial infection; antibiotics; rational use of Nosocomial infection is defined as hospital-acquired infections. It is usually due to the hospital environment, poor sanitary conditions and health care workers caused by improper operation and handling. But often overlooked another more important reason is that an unreasonable application of a large number of antimicrobial drugs is also an important factor in causing nosocomial infections. A drug-induced mechanism of nosocomial infection in Microbial ecology studies suggest that: infectious disease is a kind of ecological phenomena. Various parts of the body are usually the normal microbial communities in micro-ecosystem in its composition, structure, location and function are all in a dynamic equilibrium. If the body’s primary immune deficiencies, or because of illness, or because the immune toxicity of drugs, resulting in immune dysfunction disease, then certain parts of the body’s microbial communities change, including a special disease-causing abnormal proliferation of bacteria, or because of trauma normally sterile body sites have also established an exception microbial communities. In this way, the balance between microbes and the body was broken, so infection occurred. Fu bacteria for bacterial infections drugs designed to inhibit or eliminate the proliferation of infection in different parts of the special pathogens group or restore the normal micro-ecological balance of the site. However, therapeutic doses of all antimicrobial agents in addition to the site of infection pathogens have effect on other parts of the body also has the role of micro-ecosystem. When the use of certain antimicrobial drugs, the suppression achieved in a particular part of the MIC values of some bacteria are several times more, then the position in microbial systems by or elimination of these sensitive bac