Inhibition of tumor growth effect of matrine Research Progress.docVIP

 PAGE \* MERGEFORMAT 12 Inhibition of tumor growth effect of matrine Research Progress [Keywords:] matrine inhibited the growth of tumor cells Matrine (matrine, MAT) is a traditional Chinese medicine Sophora alkaloids contained in one of the main, found in the roots of Sophora alopecuroides, pyridine is the Fourth Ring of quinolizin class, molecular scaffold for the two quinolizin Miscellaneous pyridine ring [ 1], chemical formula C15H24N2O, molecular weight 248.36.MAT with a variety of pharmacological effects, such as: anti-bacterial anti-inflammatory, antipyretic and analgesic, expectorant asthma, cardiac diuretic, anti-arrhythmia, anti-liver fibrosis, hepatitis prevention, anti-tumor. Cancer is a serious harm to human health, disease, through efforts of several generations of medical workers, while being controlled by chemotherapy, tumor growth, but existing drug side effects of chemical drugs, causing a great burden to patients. Therefore, with anti- tumor effect, less side effects of drug-MAT, as the current hot topic. In this paper recent MAT inhibit tumor cell proliferation and induced apoptosis of tumor cells the situation further elaboration. 1 matrine inhibit tumor cell proliferation MAT can effectively inhibit tumor cell proliferation. Confirmed by the MTT method, with the MAT concentration of 0 ~ 0.5 mg mL-1 double, HT29 colorectal cancer cell proliferation inhibition rate increased gradually, in the 0.5 mg mL-1 reached maximum (86.69 + -2.38%, IC50 of the MAT concentration of 0.23 mg mL-1, in the 1.0 mg mL-1 ? inhibition rate decreased slightly, suggesting that MAT in a certain range of concentration of HT29 cell proliferation dose - relations [2]. proliferating cell antigen (PCNA is essential in the process of DNA synthesis DNA polymerase auxiliary material factor, inhibit its expression decreased proliferation of tumor cells [3], alpha-fetoprotein (AFP also could promote proliferation of tumor cells effect. There experiments s