Injection of compound cantharidin mice bearing H22 liver cancer immune regulation.docVIP

 PAGE \* MERGEFORMAT 11 Injection of compound cantharidin mice bearing H22 liver cancer immune regulation Of: Jian-Wu Zhang, Yang Ying, Zeng, Zhang Guilin [Abstract] Objective: To study the compound cantharidin Injection (Compound traditional Chinese of cantharis injection, CCI mice bearing H22 liver cancer immune effect. Methods: 2,4-dinitrochlorobenzene (2,4 dinitro chlorobenzene, DNCB skin of mice bearing H22 liver cancer induced delayed hypersensitivity (Delay type hypersensitivity, DTH, observe the CCI on mouse ear swelling, the thymus index and spleen index of the effect of the drug by radioimmunoassay bearing H22 liver cancer serum interleukin-2 (Interleukin 2, IL 2 and tumor necrosis factor @ (Tumor necrosis factor @, TNF @ levels. Results: Compared with the blank control group, model group, mouse ear swelling, the thymus index and spleen index, IL 2 and TNF @ were significantly decreased, the difference was significant (P lt;0.05, compared with model group, CCI can make mice bearing H22 liver cancer decreased ear swelling, the thymus index and spleen index, IL 2 and TNF @ levels were significantly higher (P lt;0.05. Conclusion: CCI can improve immune function in mice bearing H22 liver cancer. [Keywords:] compound cantharidin injection, immune regulation, DTH, IL 2, TNF @ In recent years, the incidence of cancer increases every year, become a major disease hazard to human health [1]. Compound cantharidin Ming Aidi injection injection products [2], is the application of modern scientific methods and prescriptions contained in the anti-tumor immunoreactive substance made of intravenous fluids purification [3], the clinical application of gastrointestinal, respiratory and reproductive system have significant effect on the tumor [4]. This experimental study of the CCI mice bearing H22 liver cancer immune regulation , discussed the role of anti-tumor mechanism of CCI. 1 Materials and methods 1.1 healthy and clean animals (SPF 120 mice, weight