Insulin receptor substrate-2 in the IUGR rat pancreas tissue of.docVIP

 PAGE \* MERGEFORMAT 7 Insulin receptor substrate-2 in the IUGR rat pancreas tissue of [Abstract] Objective To observe the intra-uterine growth retardation on the islet β -cell insulin signaling molecule insulin receptor substrate 2, the effects of intrauterine growth retardation of individual molecular mechanisms of insulin resistance. Method of low-protein diet through the establishment of intrauterine growth retardation in rats animal model study of immunohistochemical staining of insulin receptor substrate-2 in the normal diet group, rats and rats with low-protein diet after birth 0,3,8 weeks the expression of pancreatic tissue. The results of low-protein diet-induced intrauterine growth retardation in rats 0,3,8 weeks after birth pancreatic tissue of insulin receptor substrate-2 protein expression were significantly lower than the normal diet group rat pancreatic tissue of insulin receptor substrate - 2 expression. Conclusion intrauterine growth retardation on the islet β -cell insulin signaling molecule insulin receptor substrate-2 in insulin signal transduction pathway leading to obstacles, which may be intrauterine growth retardation in adult rats one of the causes of insulin resistance. [Keywords:] Fetal growth retardation; Fetal / embryology; receptor, insulin; rats; animals, laboratory [Abstract] Objective To observe the expression of insulin receptor substrate  2 (IRS  2) on intrauterine growth retardation (IUGR), and to investigate molecular mechanisms for insulin resistance in IUGR rats.Methods An IUGR animal model was established by protein malnutrition during pregnancy.Study the expression of IRS  2 by immunohistochemistry at newborn, at 3 weeks and 8 weeks respectively on control group fed with common diet and IUGR low  protein diet group.Results The level of protein of IRS  2 at newborn, 3 weeks and 8 weeks of IUGR was significantly lower than that of control group respectively.Conclusion IUGR can induce the obstacle of signal tra