Inhaled anesthetic pharmacology research.docVIP

 PAGE \* MERGEFORMAT 12 Inhaled anesthetic pharmacology research [Keywords:] of inhaled anesthetics Inhaled anesthetic blood / gas partition coefficient and tissue / gas partition coefficient determines the length of drug-induced and recovery time. If inhaled anesthetics have a higher solubility, it stays in the blood during the induction of the drug will increase, and the brain be reduced, so the induction takes a long time. sevoflurane and desflurane low solubility, blood gas partition coefficient is small, so the rapid induction and recovery. blood / gas partition coefficient is also affected by external factors. hypothermia when the numerical increase: the solubility decreased after hemodilution, the coefficient decreased. inhaled drug-induced alveolar anesthetic concentration and the ratio of inspired concentration (FA / FI) decreased with the increase of drug solubility, nitrous oxide, the FA / FI ratio, followed by desflurane, HFCs have a high fat-soluble, and thus FA / FI ratio of the lowest. Inhalation induction of anesthesia, prone to rapid increase in the concentration of the drug inhaled respiratory irritation symptoms such as cough, breath holding, laryngospasm, and salivation, etc., especially without the use of preoperative patients with the drug, which is defined to desflurane significantly. In children respiratory tract irritation than adult prison twice the machine, which may lead to lower children’s blood oxygen saturation, the occurrence of hypoxia, therefore not suitable for children desflurane anesthesia induction. If the induction of opioid analgesic drugs used before, you can reduce to halothane stimulation of the respiratory tract. halothane and sevoflurane, because there is no airway irritation, and thus suitable for the induction of anesthesia in children, sevoflurane induction of fast, less interference for the next cycle, rapid recovery, and no liver toxicity concerns, so many children to be adopted during induction of a