Inhibit the growth of corneal neovascularization Research Progress.docVIP

 PAGE \* MERGEFORMAT 11 Inhibit the growth of corneal neovascularization Research Progress Abstract corneal neovascularization (CNV) more common in infection, inflammation, trauma or corneal surgery. CNV is the ocular surface disease, one of the significant features of blood vessels of the cornea not only affected the vision, and is the main reason for corneal graft failure. In recent years, with in-depth study of the CNV, in the blood vessel formation mechanism and treatment achieved some results, mainly on Advances in Treatment of CNV were reviewed. Keywords: corneal treatment of corneal neovascularization 0 Introduction Transparent, non-vessel is an important feature of the cornea. Infection, trauma, immune response and other pathological cases, the capillaries from the limbal to the corneal growth, the formation of corneal neovascularization (corneal neovascularization, CNV). Although the infection cleared angiogenesis, wound healing, inhibit corneal dissolution, etc. have a certain effect, but the CNV can damage the cornea to normal micro-environment in which the anterior segment associated immune deviation pardon disappear, not only seriously affect the vision, but also to a significant increase in corneal graft rejection risk. In developed countries, neovascularization caused by eye diseases accounted for the top cause of blindness. In China, only on the eye injury caused by CNV represents about 10% of corneal disease, blindness caused by it has become the most prominent currently facing one of the issues. 1 CNV occurrence of the mechanism The occurrence of CNV is an extremely complex pathological process, the exact mechanism is currently not entirely clear, relevant studies have shown that, CNV mainly related to the occurrence of the following factors: (1), corneal edema; (2) promoting increased vascular endothelial growth factor; (3 ) inhibition of vascular endothelial growth factor reduced; (4) inflammatory r