Inhaled anesthetics analgesic and hypnotic effects of Mechanisms of receptor.docVIP

 PAGE \* MERGEFORMAT 15 Inhaled anesthetics analgesic and hypnotic effects of Mechanisms of receptor [Abstract] analgesic and hypnotic effects of inhaled anesthetics is the most fundamental and important role, and its mechanism is more complex, may be NMDA, GABA, glycine receptor, @ - amino acid hydroxymethyl oxazole mouth (AMPA) , neuronal nicotinic receptors and -hydroxybutyric acid (GHB) receptor and so on, in addition to other mechanisms may be involved, is to inhalation anesthetics analgesic and hypnotic effects of the relationship with these receptors are reviewed. [Keywords:] anesthetics; hypnosis; analgesic; receptor; mechanism Inhaled anesthetic induction and emergence as fast controllable anesthetic widely used in the clinic, but its exact mechanism of anesthesia is not clear [1-2]. In recent years, many in vitro studies showed that the mechanism may involve the cell membrane, a variety of receptors, ion channels and neurotransmitters [3-5], but the exact mechanism is far from clear. general anesthesia, including analgesia, hypnosis, loss of consciousness, cognitive impairment, muscle relaxation, inhibition of abnormal stress reaction, and many other aspects [6], and hypnotic, analgesic effects of its many roles in the most fundamental and important role. This paper summarizes the inhaled anesthetics analgesic and hypnotic effects and NMDA, GABA, GHB, glycine receptor, AMPA and neuronal nicotinic receptors. 1 NMDA receptor N-methyl-D-aspartate (N-methyl-D-as partate, NMDA) receptors are important to the central nervous system excitatory amino acid receptors, and pain, pain, sleep, general anesthesia and other relevant . NMDA receptors are ligand gated ion channel superfamily, is a unique double-gated channels, membrane potential control is also well received by other neurotransmitters control. Stabernack [7] found that intrathecal injection of NMDA receptor antagonist MK801 to make the minimum alveolar isoflurane effective concentrat