Inhibitor of apoptosis protein Survivin expression in osteosarcoma and its relationship with PTEN cyclinD1 protein expression in.docVIP

 PAGE \* MERGEFORMAT 22 Inhibitor of apoptosis protein Survivin expression in osteosarcoma and its relationship with PTEN cyclinD1 protein expression in Abstract [Objective] Survivin gene expression in osteosarcoma occurrence and development of the role and its relationship with PTEN, cyclinD1 protein interactions. [Methods] Immunohistochemistry (SP) method detected 40 cases of osteosarcoma, 20 cases of osteochondroma of the organization Survivin, PTEN, cyclinD1 protein expression as well as Survivin and PTEN, cyclinD1 correlation between the two proteins. [Results] Survivin in osteosarcoma, the positive rate was 62.5% (25/40), significantly higher than that of osteochondroma of 10.0% (2 / 20) positive rate (P lt;0.01). PTEN protein in osteosarcoma of the positive expression rate was 52.5% (21/40), while in osteochondroma for 95.0% (19/20), both were significantly different when compared (P lt;0.01). cyclinD1 protein in osteosarcoma, the positive rate was 80.0% (32/40), higher than Osteochondroma of 45.0% (9 / 20), there are statistically significant (P lt;0.05). Survivin and PTEN expression intensity between the two was significantly negatively correlated (P lt;0.01), while the expression of Survivin and cyclinD1 positive correlation (P lt;0.01). [Conclusion] Survivin in osteosarcoma tissue over-expression related to the occurrence of osteosarcoma; PTEN loss in osteosarcoma tissue expression, it may be reduced Survivin expression, since inhibition of osteosarcoma: Survivin and cyclinD1 in the occurrence and development of osteosarcoma may play a synergistic effect. Keywords: Osteosarcoma Survivin PTEN cyclinD1 Immunohistochemistry Expression of Survivin in Human osteosarcoma and its correlation with PTEN and cyclinD Abstract: [Objective] To investigate the expression of Survivin and its relationship with expression of PTEN and cyclinD1. [Method] Immonohistochemical method (SP method) was used to detect the expression of Survivin,