Iron oxygen free radicals and renal tubular epithelial cells.docVIP

 PAGE \* MERGEFORMAT 22 Iron oxygen free radicals and renal tubular epithelial cells Keywords:: iron tubular epithelial cells, oxygen free radicals Iron, transition state metals, one of the outer orbital electron distribution is 3d64s2, chemical nature of the lively, easy to pros and cons of electronic, resulting in highly reactive oxygen free radicals or iron oxide, iron oxide compound before, leading to tissue damage. Under normal circumstances, the body of iron to heme iron and non-heme iron and other non-response state exists, but in acute and chronic kidney disease, especially associated with proteinuria in clinical and animal models can be found in epithelial cells of tubular fluid and plasma in bleomycin-sensitive catalytic activity of iron that is a significant increase in free iron 〔 1〕 , and can accumulate in the renal proximal convoluted, distal convoluted tubule cells, lysosomes, occasionally in the mitochondria. Of iron accumulation and proteinuria, tubulointerstitial lesions, lipid peroxidation, and subtotal resection of renal glomerular filtration rate, residual kidney is directly related to the weight of such lesions 〔 1,2〕 , iron overload can increase the shortage of Renal damage susceptibility of blood 〔 3〕 ; while the renal tubular epithelial cells are the iron-mediated oxygen free radical damage from the main body, tubulointerstitial lesion is secondary damage and chronic renal units in progressive renal failure in major decisions factor 〔 2〕 . So to clarify iron, oxygen free radicals, renal tubular epithelial cell-cell interactions mechanisms are receiving increasing attention. 1, iron metabolism and renal tubular epithelial cells Proteinuria, the urinary protein excretion increased transferrin, transferrin is a major trans-shipment of iron form, relative molecular mass of 88 000, spherical, isoelectric point of 5.2, and albumin (relative molecular mass of 65 000, pI 4.7) phase ratio, its adoption glomerular membrane more by changes in