Ischemic hind limb crush injury on systemic inflammatory responses by rabbits.docVIP

 PAGE \* MERGEFORMAT 15 Ischemic hind limb crush injury on systemic inflammatory responses by rabbits [Abstract] Objective To investigate the way the two ischemic postconditioning (IP) of the hind limb crush injury the inhibitory effect of systemic inflammatory response in rabbits. Methods A rabbit model of hind limb crush injury, were used alternately clamping the open side of the common iliac dynamic crush injury Alternating bundle vein and limb crush injury proximal relaxation IP approach to the two rabbit hind limb crush injury detected before treatment, after treatment 2,6,12,24 hours after the plasma interleukin 6 (IL 6), interleukin 10 (IL 10) and tumor necrosis factor-@ (TNF @) level, compare the two treatment group and control group, these indexes. Results after IP group in the 4 time points IL 6 and TNF @ mean low water in the control group (P lt;0.05), 2,6,12 hours after treatment levels of plasma IL 10 higher (P lt;0.05); but no difference between the two IP model group (Pgt; 0.05). Conclusion IP on the hind legs crush injury in early systemic inflammatory response in rabbits was inhibited. [Keywords:] crush injury; limb; ischemia; systemic inflammatory response syndrome Abstract: Objective To discuss the inhibition of ischemic postconditioning to systemic inflammatory response syndrome (SIRS) in the model of hind limb crush injury in rabbits.Methods We established a rabbit hind limb crush injury model and two types of ischemic postconditioning in the models, ie alternately clamp / open common iliac vessel and alternately bind / loosen the proximum of hind limb, and then performed examinations on serum level of interleukin 6 (IL 6), interleukin 10 (IL 10) and tumor necrosis factor @ (TNF @) at 2 , 6,12 and 24 hours after injury.Results The serum levels of IL 6 and TNF @ at 2,6,12 and 24 hours after injury in two groups of ischemic postconditioning were higher, and a significant increase in serum level of IL 10 at 2,6 and 12 hours after inju