Klotho protein in the pathogenesis of hypertension.docVIP

 PAGE \* MERGEFORMAT 11 Klotho protein in the pathogenesis of hypertension OF: He Yajun, Su Xianming, Wang Xinyang [Abstract] Objective To investigate the klotho protein in the pathogenesis of hypertension. Methods in our hospital in March 2009 ~ June 2009, 104 cases of hypertension among hospitalized patients without hypertension and 61 blood samples, using ELISA, klotho protein, nitro-reductase assay of nitric oxide (NO). klotho protein results hypertensive absorbance and NO levels than non-hypertensive group (P lt;0.01); klotho protein absorbance and NO, the age correlation. Conclusion The Klotho protein is a protein associated with aging, possibly through nitric oxide mechanisms in hypertension. [Keywords:] Klotho protein; nitric oxide; elderly; hypertension ABSTRACT: Objective To investigate the role of klotho protein in the pathogenesis of hypertension. Methods We collected blood samples of 104 patients with hypertension and 61 people without hypertension admitted to our hospital between March and June 2009. Klotho protein and nitric oxide (NO) in blood serum were detected by ELISA and nitro reductase methods. Results Klotho protein absorbance and NO were lower in hypertension group than in non hypertension group (P lt;0.01). Klotho protein absorbance was correlated with NO and age. Conclusion Klotho protein is a protein associated with aging. Klotho protein may be involved in the pathogenesis of hypertension through nitric oxide mechanism. KEY WORDS: klotho protein; nitric oxide; aging; hypertension Department of Human Hypertension common disease. The incidence of hypertension is more genetic variation, environmental, and individual differences, and many other factors working together lead to dysfunction caused by the body, many of which mutations cause for growing concern. Klotho is Recent studies have identified a new gene, and its main expression in the kidney and brain. expressed in both human and mouse protein in the membrane-bound