Kudo Capsule Clinical analysis of closed fracture.docVIP

 PAGE \* MERGEFORMAT 7 Kudo Capsule Clinical analysis of closed fracture Of: Kang Jianping, Xu Yongxu, Wu Guanghui, Wei standard side [Keywords:] Kudo capsule, closed fracture Kudo capsule with blood and pain relief, circulation hemostatic function. To further verify the effectiveness of closed fractures and safety of patients, the author intends to expand through a multi-center clinical trial, randomized, single blind, positive parallel control method its an objective evaluation. 1 Experimental Design 1.1 Test methods and procedures A randomized, single blind, positive controlled clinical research methods in parallel. Test selected patients with closed fractures of tibia and fibula, respectively, after administration of drugs reduction was observed for 4 weeks. 1.2 delivery methods Experimental group was treated Kudo capsules (Bio Pharmaceutical Co., Ltd. Gansu Kudo production, batch number size: 0.3 g / grain), 3 tablets / time, 3 times / d, for 4 weeks. Yunnanbaiyao control group oral capsule (Yunnanbaiyao Co., Ltd., batch number size: 0.25 g / grain), 2 / 4 times / d, for 4 weeks. 2 Case Selection 2.1 the inclusion criteria [1] ① violence directly or indirectly, history of trauma. ② symptoms of closed tibial fractures without complications, severe systemic symptoms was not obvious or not. ③ X-ray examination by a clear fracture of tibia and fibula. ④ accepted within 2 weeks after injury surgery. ⑤ TCM as blood stasis, showed no fractures or bone with no firm connection, pain reduction, swelling eliminate entirely, dark red tongue, thin yellow coating, pulse string. 2.2 Exclusion criteria ① from the bone disease (benign or malignant tumors, tuberculosis, osteomyelitis, endocrine and metabolic and other factors) caused by pathologic fracture. ② open fractures with soft tissue defects or infection. ③ breastfeeding, pregnant or are planning pregnancy, women . ④ allergies or multiple drug allergies. ⑤ co