Later on rabbit prostaglandin reperfusion Ion Channels.docVIP

 PAGE \* MERGEFORMAT 11 Later on rabbit prostaglandin reperfusion Ion Channels [Abstract] Objective To study the forefront in later on rabbit ischemia / reperfusion myocardial cell membrane ion channel activity and on ischemia / reperfusion protection mechanisms. Methods myocardial ischemia / reperfusion model, 32 male Japanese white rabbits were randomly divided into 4 groups: sham operation group (S), ischemia reperfusion group (I / R), ischemic postconditioning group (I post), and later treated with prostaglandin (PGE). Determination myocardial soluble intercellular adhesion molecule 1 (sICAM 1) and myeloperoxidase (MPO) content and Na + K + ATP enzyme and Ca2 + ATP activity. Results and I / R group, I post and the PGE group myocardial sICAM 1, MPO was significantly reduced and ion channel activity was significantly higher (P lt;0.01). Conclusion Prostaglandin later treatment reduced neutrophil infiltration, increased ion channel activity, which might be playing one of the mechanisms of protective effects. [Keywords:] Na + K + ATP enzyme; Ca2 + ATP enzyme; myocardial ischemia / reperfusion; alprostadil; post-processing Revascularization after the impact of reperfusion injury in acute myocardial infarction has become an important factor in the prognosis of patients, ischemia / reperfusion (I / R) injury is one of the mechanisms of excessive inflammatory response. Neutrophils by a variety of pathway mediates I / R injury (1), inhibition of cell membrane ion channel activity is one of the ways of their injured myocardium. post-processing without pre-judging the occurrence of disease, easy to implement in clinical practice. Lipo-Alprostadil is based on targeting concept of drug delivery is made of prostaglandin E1 (PGE1), based on experiments confirmed that (2,3), at the end of reperfusion before ischemia or after the grant of alprostadil, can significantly reduce the myocardial ischemia reperfusion injury. However, the myocardium given the beginning of