Li and the crowd thalassemia gene screening methods of.docVIP

 PAGE \* MERGEFORMAT 8 Li and the crowd thalassemia gene screening methods of Keywords:: thalassemia; multiple PCR; Screening Abstract: Objective To find a group of screening for thalassemia gene approach. Methods of multiple PCR technique, a reaction to weed out the β -thalassemia carriers (β ° CD41/42) and the α 2 gene deletion carriers. Results 1207 cases of Li groups weed out the β ° CD41/42 (-TCTT)-thalassemia carriers in 123 cases (10%). Screen out the α 2 gene deletion 212 cases of the whole (of which HbH disease 3 cases). Conclusion This method is suitable for Li and the crowd thalassemia gene screening. Keywords:: thalassemia; multiple PCR; Screening Investigation into the methods of screening thalassemia gene in LI Nationality population in Hainan. Abstract: Objective To find a method that can be used for massively screening of thalassemia gene Li Nationality community. Methods Multiplex-PCR was used for screeningβ -thalassemia carriersβ ° CD41/42) and theα 2 gene deficient carriers in a sin-gle reaction. Results Out of the1207Li Nationality samples123thalassemia carriers (accounted for10%) and212completeα 2 gene deficient carriers (including3HbH disease patients) were detected. Conclusion The method is suitable for scredning tha-lassemia gene carriers in Li Nationality population. Keywords:: Thalassemia; Multiplex-PCR; Screening Thalassemia is common in southern China, an inherited blood diseases, their common feature is due to globin gene deletion or defect to the globin chain of hemoglobin synthesis was inhibited, resulting in changes in the structure of hemoglobin ingredients clinically with chronic progressive hemolytic anemia as the main performance, light may be no or only mild anemia, severe cases, severe anemia, hepatosplenomegaly, growth retardation and bone changes, etc. In addition to stem cell transplantation is currently no other effective cure outside the method. Blood transfusion in children with severe needs