Lipid emulsion of bupivacaine recovery mechanism of cardiac arrest caused by.docVIP

 PAGE \* MERGEFORMAT 17 Lipid emulsion of bupivacaine recovery mechanism of cardiac arrest caused by Of: Shi Tong, Liu Yue, Shi Kejian, royal light, Chen Ying, Wang Fang Yan, Xu Xuzhong [Abstract] Objective?: To investigate the reversal of bupivacaine cardiac toxicity of fat emulsion possible mechanism. Methods: SD 72 male rats were randomly divided into six groups: A group (bupivacaine induced cardiac arrest and resuscitation of fat emulsion ), B group (bupivacaine induced cardiac arrest KH perfusion group), C group (bupivacaine induced cardiac arrest group), D group (25 min equilibrium perfusion group), E group (including the fat emulsion KH perfusion group), F group (KH perfusion group), 12 in each group. recorded heart rate during reperfusion - left ventricular developed pressure product (RPP), stop filling when the determination of myocardial adenosine content in each group and the bupivacaine due to concentration. Results: A group of resuscitation number of cases, early resuscitation number of patients were significantly more than the B group (P? lt;0.01). A group of resuscitation was significantly shorter than B group (P? lt;0.05). resuscitation after within 40 min, A group of RPP were significantly higher than that of B group (P? lt;0.01). A group of EC was significantly lower than the B group (P? lt;0.05). bupivacaine concentration in cardiac tissue from high to Low order of group Cgt; B groupgt; A group (P? lt;0.01). Conclusion: The fat emulsion of bupivacaine concentration of reducing myocardial tissue, is the reversal of bupivacaine cardiac toxicity, the main mechanism. [Keywords:] fat emulsion; bupivacaine; cardiac resuscitation; cardiac arrest, artificial; rat Abstract:? Objective: To explore and discuss the possible mechanism of lipid emulsion to rescue the bupivacaine-induced cardiac arrest. Methods:? The hearts of male Sprague-Dawley rats were excised and retrogradely perfused in an nonrecirculating Langendorff preparation. They wer