Liposome drug delivery targeting Chinese Progress.docVIP

 PAGE \* MERGEFORMAT 19 Liposome drug delivery targeting Chinese Progress [Keywords:] Chinese Research liposome targeted drug delivery Is a pure natural products and traditional Chinese medicine can treat many incurable diseases, at present, Chinese are the world’s attention. The inclusion of modern science and technology, emulsion technology, supercritical fluid extraction (SFE), ultrafiltration (membrane separation), solid dispersion, liposome technology has gradually been applied to production practice, which has enhanced efficacy of liposome technology, targeted drug delivery to extend the duration of action, reduced side effects the characteristics of its targeting of preparation attention. liposome technology to the development and production among the Chinese, traditional Chinese medicine in China will have a positive impact. This paper reviews the liposome targeted drug delivery technology in the case of traditional Chinese medicine. 1, the structure of the liposomes and the mechanism of targeted drug delivery Liposome drug delivery system is a directed, the drug is encapsulated in the lipid (phospholipid and cholesterol) bilayer films formed micro-spherical body made of the middle. Bilayer inside and outside the fat-soluble and water-soluble drugs were encapsulated , its physical and chemical properties and structure similar to the cell membrane, also known as artificial membrane. Liposomes into the body of Chinese medicine is primarily phagocytic reticuloendothelial system, thereby activating the body’s own receptors and changes in immune function in vivo distribution of drugs to be encapsulated, so that drugs, primarily in the liver, spleen, lung and bone marrow and other organs in savings, thereby enhancing the bioavailability of drugs to reduce the dose of drugs and reduce drug toxicity and reduce adverse reactions, slow release, reducing the body to eliminate the speed, changing the distribution of drugs in the body, and to targeted