Li people in Hainan angiotensin-converting enzyme 2 gene polymorphism with hypertension.docVIP

 PAGE \* MERGEFORMAT 8 Li people in Hainan angiotensin-converting enzyme 2 gene polymorphism with hypertension OF: Ken Gold Crystal Zhou Yong Feng Wu ZHANG Yun-xia Chen Shaohua Li Linjiang Wang Zhen Xi Li Jun, Zhao Qing Chen [Abstract] Objective To investigate the Li people in Hainan angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and the relationship between high blood pressure. Methods Polymerase chain reaction-restriction fragment length polymorphism detection of the hypertension group and control group ACE2 gene G8790A polymorphism between, and speculated that ACE2 gene polymorphisms and the incidence of hypertension. Results of hypertension compared with the control group, men with hypertension group was significantly different (P lt;0.05), women in the gene expression type and gene frequencies between groups were not statistically significant (Pgt; 0.05). Conclusion ACE2 gene G8790A polymorphism and the Hainan Li incidence of hypertension in men have a certain relationship. [Key Words] essential hypertension; angiotensin-converting enzyme 2; gene polymorphism Studies have shown that the human angiotensin converting enzyme (ACE) gene polymorphism associated with the occurrence of hypertension (1,2) .2000 by Donoghue et al (3) and Tipnis, etc. (4) found that, ACE2 and ACE incidence Instead the role of physiological activity, so that people renin-angiotensin aldosterone (RASS) a new understanding of the system. ACE2 gene polymorphism and cardiovascular disease related research has become a new hot spot. ACE2 rare home and abroad the relationship between gene polymorphism and hypertension reported Li from this study population ACE2 gene polymorphism with hypertension relationship. 1 Subjects and methods 1.1 All subjects who were selected from March 2007 to August 2009 Lingshui, Changjiang County Hospital inpatient and outpatient Li patients. Among them, 80 cases of hypertension, 43 males and 37 females, aged 43 ~ 72 years, mean