lipoic acid on bone metabolism in young rats exposed to lead influence.docVIP

 PAGE \* MERGEFORMAT 14 lipoic acid on bone metabolism in young rats exposed to lead influence Study: Dan Pei, Zheng Deyu, single-wei, Qin Shujian [Abstract] Objective @ lipoic acid on bone metabolism in rats exposed to lead. Methods to 31 SD rats were randomly divided into 2 groups, control group 8 and the lead exposed group (230mg / L lead acetate gavage) 23, 40d after 3 rats from each group were measured blood lead and bone lead, will have lead exposed rats were randomly divided into 4 groups, namely, lead control group, 3 @ lipoic acid treatment groups [30,60,100 mg / (kg d)] n = 5. @ lipoic acid treatment of animals were sacrificed after 80d, measured blood lead, bone lead, osteocalcin radioimmunoassay method to measure the content of alkaline phosphatase expression was detected by immunohistochemistry. Results @ lipoic acid treated group blood lead and bone lead levels were lower than the lead in the control group, the difference was statistically significant (P lt;0.05). @ 100mg lipoic acid content of treated rats osteocalcin, alkaline phosphatase expression and lead the control group, the difference was statistically significant (P lt;0.05). Conclusion @ lipoic acid can reduce the toxicity of lead on the role of bone metabolism. [Keywords:] @ lipoic acid; lead; bone; osteocalcin; alkaline phosphatase ABSTRACT: Objective To determine the effects of @ lipoic acid on bone metabolism in lead poisoned rats.Methods Totally 31 SD rats were randomly divided into two groups, 8 rats in blank control group and 23 in lead group that received gastric lavage with lead acetate ( 230mg / L). After 40 days, 3 rats from each group were taken for the measurement of lead in the blood and bone. The rats in lead group were then randomly divided into four groups: lead control group and three lead groups with different concentrations of @ lipoic acid [30, 60 and 100mg / (kg d)], with 5 rats in each. At the end of the experiment (80d), the rats were killed and t