Liposome preparation methods and research.docVIP

 PAGE \* MERGEFORMAT 20 Liposome preparation methods and research [Abstract] The current commonly used two types of liposome preparation methods: passive and active drug-loading method of Drug Act, and its advantages and disadvantages compared. The passive method is suitable for fat-soluble drug-loaded strong drug encapsulation efficiency high and difficult to reveal; and active drug-loaded method is suitable for two pro-drugs. [Keywords:] liposome; passive drug-loaded; active drug-loaded Liposomes as drug carriers have to improve drug efficacy, reduce adverse drug reactions and targeting role of the character. 30 years, people have done a great deal of their preparation methods research. Liposomes by phospholipid molecules in the aqueous phase through the formation of hydrophobic interactions, so the preparation of liposomes is not emphasized in membrane assembly, but how the formation of the appropriate size, encapsulation rate and high stability of the vesicles. Preparation methods, liposome size from several tens of nanometers to several microns, and the structure is not the same. At present, the method of preparation of liposomes are more commonly used with thin-film method, reversed-phase evaporation method, solvent injection method and the double emulsion method, etc., these methods commonly referred to as a passive drug-loading method, while the pH gradient method, ammonium sulfate gradient method generally known as the active drug-loading method. A passive drug-loading method Liposome preparation methods used are mainly thin-film dispersion method, reversed-phase evaporation method, injection method, ultrasonic dispersion. In the preparation of drug-containing liposomes, the first phase of drug soluble in water or organic phase, and then press the appropriate drug-containing liposomes were prepared by the method is suitable for a strong fat-soluble drugs, liposomes have a higher income encapsulation efficiency. 1.1 The thin-film dispersion method