STAT-3持续活化与肿瘤侵袭、转移.pdfVIP

第 16 卷第 4 期 生命科学研究 Vo1.1 6 No.4 2012 年 8 月 Life Science Research Aug.2012 ·综述· STAT-3 持续活化与肿瘤侵袭、转移 邹黎黎，韩莉，柳长柏* (三峡大学医学院，中国湖北宜昌 443 (02) 摘 要: JAK-STATGanus tyrosine kinase-signal transducer and activator of transcription) 细胞信号转导途径的紊乱， 是肿瘤发生最重要的原因之一.近年来的研究发现， STAT-3 作为 JAK-STAT 信号转导途径中一个重要的调节 分子，能够通过将信号直接转导入细胞核而快速激活下游基因，从而保证相应国己体顺利完成信号转导过程.然 而， STAT-3 也有其黑暗的一面，其往往在恶性肿瘤细胞中表现为持续活化，作为一种原癌基因，成为肿瘤治 疗的新靶标.因而，对近年来有关 STAT-3 的持续活化与恶性肿瘤细胞的侵袭、转移过程及肿瘤千细胞的关单 作一概述，有助于深入了解 STAT-3 在肿瘤发生发展机制中发挥的作用. 关键词:信号转导子 a转录激活子 -3(STAT-3); 持续活化;肿瘤侵袭与转移;癌症干细胞 中商分类号: R730.22 文献标识码 :A 文章编号: 1007-7847(2012)04-0372-05 Constitutive Activation of STAT -3 and Neoplasm Invasion and Metastasis ZOU Li-li, HAN Li, LIU Chang-bai* (Medical College, China Three Gorges Unìversity, Yìc 加ng 443002, Hubei, Chìna) Abstract: The disorder of JAK-STAT(janus tyrosine kinase-signal transducer and activator of transcription) is one of the leading causes for the occuπence of tumors. Recent studies showed that STAT-3, an important transcription factor of JAK-STAT signal transduction pathway, can promote the rapid induction of genes by directly transducing signals from the receptor into the nucleus, and to play a pivotal role in mediating th e biological response for this lìgands. However, STAT-3 appears to have a dark side as well. STAT-3 can sus? tainablely activate in the tumor cells, and serve as a new target for tumor therapy as a protooncogene. Thus, it is helpful to gain a better understanding of the role of STAT-3 in tumorigenesis with the overview of the relationship betwee