Methylprednisolone treatment of multiple sclerosis mechanism.doc

 PAGE \* MERGEFORMAT 16 Methylprednisolone treatment of multiple sclerosis mechanism [Keywords:] multiple sclerosis; methylprednisolone [Keywords:] multiple sclerosis; methylprednisolone 0 Introduction Multiple sclerosis (MS) exacerbation of the treatment of commonly used drugs is one of methylprednisolone, which can speed up the exacerbation of mitigation has been proven, but its mechanism is unclear. In this paper, from the perspective of MS etiology to analyze the possible role of methylprednisolone in the mechanism. The nature of a methyl-prednisolone Methylprednisolone (Methylprednisolone, MP) for the glucocorticoid one of its wide range of pharmacological effects. Generally considered: glucocorticoids through the dispersion into the target cells, and its receptor to form a steroid - receptor complex; activated steroid - receptor complex as a gene transcription activator activity to play its role in regulation of gene transcription; leading to an increased mRNA synthesis, thus affecting the synthesis of protein to play its pharmacological effects. which is a kind of methylprednisolone the effect of synthetic glucocorticoid (unlike hydrocortisone, in order to short-acting corticosteroid) is in the prednisolone (Prednisolone) the introduction of methyl-6α -bit to enhance the anti-inflammatory effects (for hydrocortisone pine 7 times), water and salt metabolism and weaken. intravenous injection because of its fast onset of action, effect lasting, less side effects and other advantages, and its wide range of clinical applications. 2 Multiple Sclerosis MS is a central nervous system inflammatory demyelinating disease, its exact cause is unknown. However, the study suggests a number of susceptibility genes and environmental factors together lead to MS pathogenesis. Because of its higher rate of incidence of chronic diseases was the agenda and tend to disorders in young people, and become the most important diseases of the nervous system. at home, MS acut