Micronization of icariin in epimedium leaf extract Effect of.docVIP

 PAGE \* MERGEFORMAT 7 Micronization of icariin in epimedium leaf extract Effect of Author: Xu Xiuli, Zhang Mingchun, Zhang Xu, office, small Hongyuan, SONG Fu-line [Abstract] Objective To study the micronization of icariin in epimedium leaf extract rates. Methods Epimedium leaves as raw material, the traditional hammer smash as control, through the orthogonal design, study QM  ISP12 planetary ball milling powder machine configurations, time and speed of the active ingredients of which the rate of extraction of icariin impact. In which the content of icariin using high performance liquid chromatography method. Results Hammer Icariin controls extraction rate 0.78%, while the orthogonal micro-grinding technology, the highest extraction rate was 1.12%. Obtained by analyzing the orthogonal design, configured for φ 6 mm balls of steel ball 800, φ 10 mm of the steel ball 100, φ 20 mm of the steel ball 6, the time for 1 h, rotational speed 350 r / min is the best technology, the actual extraction rate of 1.25%, higher than the hammer-type controls. Conclusion After planetary ball mill micronization epimedium leaves can increase the extraction yield of icariin. [Keywords:] icariin Epimedium leaf powder technology, high performance liquid chromatography by orthogonal design Micronization is to improve drug solubility and bioavailability of the effective means of traditional Chinese medicine powder is a traditional Chinese medicine modernization of the new technology research focus. Current research focuses on the micronization of drugs active ingredient or parts of the dissolution rate and efficacy of [1]. CAI Ping, etc. [2,3] studied the general indicators of powder and powder components of Danshen cryptotanshinone, tanshinone Ⅱ A and protocatechuic aldehyde extraction rate and found that both enhance the fat-soluble Danshen micronized ingredients cryptotanshinone and tanshinone Ⅱ A extraction rate, but also improve the water-soluble components of the extractio