Microwave Synthesis of nitro-7 4 (3H)quinazolinone.docVIP

 PAGE \* MERGEFORMAT 19 Microwave Synthesis of nitro-7 4 (3H)quinazolinone Of: Kehong Qin Liu Yingxiang, Zhu Yuxiang [Abstract] Objective Synthesis of 7-nitro microwave radiation 4 (3H) quinazolinone, microwave power, microwave irradiation time and the molar ratio of amine on the reaction yield. Methods of 2-Amino-4-nitrobenzoic acid , formamide was prepared by microwave irradiation Synthesis of 7-nitro-4 (3H) quinazolinone and optimized by orthogonal experimental conditions. Results optimum conditions: microwave power 95 W, irradiation time of 9 min, amine molar ratio of 1:12, the yield up to 96.8%, compared with conventional heating increased by about 35%. Conclusion of microwave radiation on the synthesis of 7-nitro-4 (3H) quinazolinone with very good results, with the traditional heating methods and literature compared to shorten the reaction time and increase the reaction rate and yield. [Keywords:] 7-nitro-4 (3H) quinazolinone orthogonal design of microwave radiation Abstract: Objective To evaluate the effect of microwave irradiation on the synthesis of 7 nitro 4 (3H) quinazolinone was investigated.Method 7 nitro 4 (3H) quinazolinone was synthesized from 4 nitroanthranilic acid and formamide under microwave irradiation. The reaction conditions were optimized with orthogonal design. Result The optimum conditions were determined as follows: microwave power was 95 W, irradiation time was 9 min, and the molar ratio of 4 nitroanthranilic acid to formamide was 1:12. Under above conditions, the yield of product might reach 96.8 %, increasing by 35% compared with conventional method.Conclusion 7 nitro 4 (3H) quinazolinone was synthesized successfully under microwave irradiation. Compared with conventional method, the reaction time shortened and the reaction efficiency increased. Keywords:: 7 nitro 4 (3H) quinazolinone; microwave irradiation; orthogonal design Substituted 4 (3H) quinazoline ketones is a kind of biological activity of a wide range