midkine Ki-67 and CD34 in endometrial carcinoma and its significance.doc

 PAGE \* MERGEFORMAT 18 midkine Ki-67 and CD34 in endometrial carcinoma and its significance [Abstract] Objective To investigate the midkine (midkine, MK, Ki-67, CD34 in the normal endometrium, endometrial intraepithelial neoplasia (EIN tissue, endometrial cancer tissues and its biological behavior significance. Methods 15 cases of normal endometrium, 20 cases of EIN organizations and 30 cases of endometrial cancer tissue samples, immunohistochemical method (SP method were detected by MK, Ki-67, CD34 expression, and statistical analysis. Results MK, Ki-67, CD34 in the normal endometrium, EIN and endometrial cancer tissues gradually increased, and its expression in 3 tissues were significant differences between (P lt;0.05 , MK, Ki-67 and CD34 expression and clinical stage of endometrial cancer, histological grade, lymph node metastasis, tumor myometrial invasion and other related (P lt;0.05, and endometrial cancer patients with age ( Pgt; 0.05), MK and Ki-67 in endometrial carcinoma was positively correlated (r = 0.781, P lt;0.05. Conclusion The positive expression of MK and the incidence of endometrial cancer, development and prognosis, can the United Ki -67 and CD34 as a valuable tumor marker and prognostic indicator. [Keywords:], endometrial cancer, midkine, Ki-67, CD34 Abstract: Objective To investigate the expressions and significance of biological behavior of midkine, Ki-67 and CD34 in normal endometrial tissues, endometrial intraepithelial neoplasia (EIN) and endometrial carcinoma. Methods A total of 15 samples of normal endometrial tissue, 20 samples of endometrial intraepithelial neoplasia and 30 samples of endometrial carcinoma were examined for the expression of MK, Ki-67 and CD34 by immunohistochemical method (SP) and statistical analysis of the results. Results The positive expressions of MK, Ki-67 and CD34 in endometrial carcinoma were significantly higher than in endometrial intraepithelial neoplasia and normal endometrial tissue (P lt;