Microbial conversion technology in the modern pharmaceutical industry in the application of.doc

 PAGE \* MERGEFORMAT 25 Microbial conversion technology in the modern pharmaceutical industry in the application of Keywords: microbial conversion technology ;,,,, biocatalysis ;,,,, the key intermediate of Abstract: The microbial conversion technology applications in the modern pharmaceutical industry’s unique advantages, especially in the intermediate chiral drugs or drug preparation, use of microbial transformation of means of implementation of the combination of bio-catalysis in drug screening has played an active role elaborated analysis and combined with the author’s own in recent years in the technology practice in the field and harvesting on a number of related topics are presented. Keywords:: microbial conversion technology; bio-catalysis; the key intermediate Application of microbial transformation in modern pharmaceutical industry KEY WORDS Microbial transformation; Biocatalysis; Key intermediates 1 Overview In the past 30 years, microbial transformation or enzymatic conversion technology in the field of organic synthesis in the attempt to not only been widely carried out theoretical studies, practical applications have also made considerable progress. Many chemical synthesis of complex drugs, food additives, vitamins, cosmetics and other fine chemical products in the synthesis of some important reaction, at present has been able to use microbial or enzymatic conversion technologies to be replaced. In a number of foreign literature often be able to see the description of the terms of this technology are: microbial transformation, microbial conversion, biotransformation, biotransconversion and enzymation etc. [1,2]. Is the essence of microbial transformation of some kind of micro-organisms to a substance (substrate) transformed into another substance (product) process, this process is produced by some kind of micro-organisms of one or several specific extracellular or intracellular enzymes as biological catalysts i