Metabotropic glutamate receptor subtype 5 with cerebral infarction.docVIP

 PAGE \* MERGEFORMAT 18 Metabotropic glutamate receptor subtype 5 with cerebral infarction [Keywords:] Cerebral Infarction Cerebral infarction in the elderly population in China is currently in the common disease. With the progress of molecular biology, the pathogenesis of cerebral infarction has been more in-depth understanding of proposed free radical damage, excitotoxicity, a nitric oxide (NO) doctrine, mild hypothermia therapy, theory of energy failure, calcium channel blockers and other theories. Recently on glutamate receptor-mediated neurotoxicity study more, especially in the metabotropic glutamate receptors on increasingly attention, including metabotropic glutamate receptor 5 (mGluR5 and cerebral infarction has been widespread concern. 1 metabotropic glutamate receptors (metabotropic glutamate receptors, mGluRs) classification Mammalian central nervous system glutamate is the major excitatory neurotransmitter of excitatory synaptic transmission from the regulation, the physiological conditions in the regulation of many physiological functions, such as learning and memory, neural development, etc. . in cerebral ischemia, brain injury, seizures, neurodegenerative diseases and other pathological process, glutamate also plays an important role. Currently the glutamate receptor (GluR ligand binding by the effects of the different sub- into two categories: ionotropic glutamate receptors (inotmpic glutamate receptors, iGluRs), including the NMDA receptor, AMPA receptors and KA receptors, mGluRs, mGluRs according to amino acid sequence homology, pharmacological properties and intracellular signaling transduction differences, can be divided into Group-, Group- and Group- three groups: (1Group , including mGluR1 and mGluR5, mainly through the activation of phospholipase c (PLC), to promote muscle phosphatidylinositol diphosphate alcohol (PIP2 into diacylglycerol acyl ester hydrolysis (DG), lead to intracellular Ca2 + concentration, (2Group includ