Mifepristone clinical applications in obstetrics and gynecology.docVIP

 PAGE \* MERGEFORMAT 5 Mifepristone clinical applications in obstetrics and gynecology [Abstract] mifepristone in obstetrics and gynecology in the applications are not limited to termination of the early and middle pregnancy, and gynecological tumors and in recent years in the application of emergency contraception has also been taken seriously, but also for advanced cervical ripening and induction of labor. proposed clinical application of mifepristone in obstetrics and gynecology and has broad prospects. [Keywords:] mifepristone in obstetrics and gynecology Anti-progesterone mifepristone successful development of drug alternative to surgical termination of early pregnancy becomes a reality, in recent years, anti-tumor, emergency contraception, cervical ripening in late pregnancy and induced abortion, ectopic pregnancy, menopause, blood work and other aspects of application also attracted attention. 1 Pharmacological characteristics of mifepristone Anti-progestin mifepristone (RU486 is a synthetic steroid, norethindrone like its structure, there is resistance to glucocorticoids, the role of anti-progesterone and abortion, he absorbed quickly, and peaked 1 hour after medication, a long half-life ( 25 to 30 hours, no accumulation effect, steady-state blood concentration high. 2 of pregnancy with mifepristone 2.1 The study has been affirmed by the first trimester abortion, mifepristone and misoprostol (MP compatibility the best way for the present, therefore, medical abortion using RU486 Compatibility MP has been widely used clinically, its safety and efficacy compared with affirmed The clinical observation that the pregnancy success rate of 49 were the highest, while the smaller side, but 90 days of pregnancy to the compatibility of MP after oral administration of vaginal administration of RU486, the abortion rate than the compatibility of the safety of oral MP high, and fewer side effects. 2.2 pregnancy trimester abo