MMP2 and VEGF in osteochondroma giant cell tumor and osteosarcoma tissues and its clinical significance.doc

 PAGE \* MERGEFORMAT 14 MMP2 and VEGF in osteochondroma giant cell tumor and osteosarcoma tissues and its clinical significance Abstract Objective To study the matrix metalloproteinase 2 (MMP 2) and vascular endothelial growth factor (VEGF) in cartilage tumor of bone giant cell tumor and osteosarcoma tissues and clinical significance. Methods Immunohistochemical staining for MMP 2 and VEGF in osteochondroma, giant cell tumor and 20 cases of osteosarcoma in the expression and its relationship with age, gender and recurrence, metastasis and other factors. Results VEGF and MMP 2 in giant cell tumor and osteosarcoma group, positive rate (60%, 70%; 90%, 80%) was significantly higher than that of cartilage tumor group (25%, 30%) (P lt;0.05, P lt;0.01), and the expression of both a significant positive correlation (P lt;0.05). MMP 2 and VEGF were correlated with recurrence and metastasis was significantly associated (P lt;0.05, P lt;0.01), with age and sex. Conclusions MMP 2 and VEGF could be used as giant cell tumor and osteosarcoma prognosis. Keywords: matrix metalloproteinase 2; vascular endothelial growth factor; osteochondroma; bone giant cell tumor; osteosarcoma Recent studies suggest that 1,2, matrix metalloproteinase (MMP) and vascular endothelial growth factor (VEGF) and tumor invasion and metastasis. VEGF and MMP 2 have been reported in the presence of high expression of bone tumors, but also closely related with the metastasis and recurrence 3,4, but has not been combined detection of MMP 2 and VEGF in osteochondroma, giant cell tumor and osteosarcoma Expression and clinical significance of the report. In this study, immunohistochemical method to be adopted, the joint detection of VEGF and MMP 2 in the cartilage tumor of bone giant cell tumor and osteosarcoma tissues, and its relationship with age, gender and recurrence, metastasis, compare The difference between and correlation. 1 Materials and methods 1.1 Clinical data osteochondroma,