Modified Huanglian Ejiao Tang Duishun platinum renal toxicity in rats the expression of TGF1.doc

 PAGE \* MERGEFORMAT 11 Modified Huanglian Ejiao Tang Duishun platinum renal toxicity in rats the expression of TGF1 Of: Yang Gui Liu Na Yang Yanmei Wang Xiaoyu dye Shwn-Jen Lee [Abstract] Jiao Tang Modified Huanglian observed on the expression of TGF 1. [Methods] SD rats were randomly divided into 5 groups of 12. In addition to the normal control group, the rest of the group were given DDP5mg/kg, normal control group DDP with the same amount of normal saline intravenously. Modified Huanglian Ejiao soup low dose group and high dose group were given Modified Huanglian Ejiao soup, Used for 8 weeks, the treatment group was injected with sodium thiosulfate with cisplatin at the same time, give thiosulfate sodium injection. end of the experiment to collect 24h urine protein in urine, urinary NAG levels, measured femoral artery blood creatinine, blood urea nitrogen level, split renal tissues obtained HE, immunohistochemical staining, detection of TGF 1 in renal tissue expression, measured by image analysis of protein expression of TGF 1 mean absorbance values. [Results] rats 24h urinary protein, NAG levels and serum creatinine, blood urea nitrogen were significantly higher than the normal control group. After treatment sodium thiosulfate treatment group and each group Modified Huanglian Ejiao soup 24h urinary protein, NAG and serum creatinine levels, blood urea nitrogen were significantly lower than the model group, compared with the control group no significant difference. Compared with model group , Modified Huanglian Ejiao soup sodium thiosulfate in each group and treatment group the mean absorbance of TGF 1 were significantly different, and Jiao Tang Modified Huanglian sodium thiosulfate in the treatment group than the treatment group. [Conclusion] Modified Huanglian Ejiao Decoction reduce cisplatin nephrotoxicity in rats 24h Upro, NAG and serum creatinine levels, blood urea nitrogen levels, reduced renal tubular epithelial cells the expression of TGF 1, to