Muscle relaxants on narcotic prevention of complications.doc

 PAGE \* MERGEFORMAT 8 Muscle relaxants on narcotic prevention of complications [Keywords:] prevention of complications of muscle relaxants A depolarizing muscle relaxant succinylcholine 1. Succinylcholine clinical applications and complications of succinylcholine is commonly used depolarizing muscle relaxants, and its many complications is determined by its mechanism of action, pharmacokinetics, or cause a specific reaction, such as burns, trauma, high and lower motor neuron damage and patients with various myopathies shortly after succinylcholine, hyperkalemia and cardiac arrest can occur, and prolonged muscle relaxation (due to phase Ⅱ block), also sometimes appear neuromuscular block delay. succinylcholine short duration of action was caused by the rapid hydrolysis of pseudo-cholinesterase caused reduced when the number of false or atypical cholinesterase and abnormal variation in the presence of pseudo-cholinesterase, amber choline’s role will be delayed. normally occurs in skeletal muscle end plate depolarization effect of acetylcholine receptors on the device, with K + after succinylcholine spillover will lead to increased serum potassium 5mmol / L or so, but in some pathological conditions, serum potassium concentration will be greatly increased. In the state of the patient to the nerve, acetylcholine receptors, muscle high sensitivity, have played almost the entire fascia end plate effect. sodium and potassium to increase the penetration area, resulting to polarized sodium and potassium, a potassium move to increase the outflow increased. The incidence of hyperkalemia after injury to some extent dependent on the type of injury and the subsequent high-min acetylcholine receptor status. Application of non-depolarizing muscle relaxant pretreatment, does not eliminate the response of hyperkalemia. In infants and children, myopathy was not obvious in the clinical presentation, only the application of hyperkalemia after succinylcholine can be diagnose