Myocardial ischemia in acute myocardial expression of AT1-AT2.doc

 PAGE \* MERGEFORMAT 10 Myocardial ischemia in acute myocardial expression of AT1/AT2 Of: Liushi Li Kang Jinsong Wang Weiwei Zhong Qu Xian Zhi Yu Hui Kato Yong Ning Li Hongyan U.S. Abstract acute myocardial ischemic myocardial tissue renin - angiotensin system (RAS) of the expression. Methods The left anterior descending coronary artery ligation in acute myocardial ischemia model replication. Determined by RT PCR of myocardial tissue angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin type 1 receptor (AT1) / angiotensin type 2 receptor (AT2) and water channel protein 4 (AQP4) mRNA expression. Results Compared with the sham group, acute myocardial ischemia rats were not significantly changed in the AGT mRNA, ACE and AT1 mRNA expression was significantly lower (P lt;0.05), AT2, and the expression of AQP4 mRNA was significantly higher (P lt;0.05). Conclusion Local RAS and AQP4 in the process of acute myocardial ischemia. Keywords: renin angiotensin system; myocardial ischemia; angiotensin type 1 receptor; angiotensin type 2 receptor; water channel protein 4 Studies show that most renin angiotensin system (renin angiotensin system, RAS) components in the heart, brain, kidneys, blood vessels and other tissue formation, while the local RAS through autocrine, paracrine and endocrine cell method independent of organ function and, in some cardiovascular diseases such as ischemic heart disease, hypertension, cardiac hypertrophy, congestive heart failure, etc. play an important role in the development 1, but the specific mechanism is not very clear. In this study, ligation of the anterior descending coronary artery in acute myocardial ischemia model replication, determined by RT PCR myocardial RAS system angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin 1 receptor (AT1), angiotensin type 2 receptor (AT2) and water channel protein 4 (aquaporin4, AQP4) mRNA, further explore the local RAS system in acute myocardi