Nacetylcysteine on oxidative stress in elderly patients with COPD and pulmonary function.doc

 PAGE \* MERGEFORMAT 11 Nacetylcysteine on oxidative stress in elderly patients with COPD and pulmonary function Author: Li Jing Council, Hui, Yu Wu, Xia loyalty [Keywords:] Chronic obstructive pulmonary disease; N-acetyl-cysteine; oxidative stress Chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD) is a kind of a disease characterized by limited airflow, airflow limitation is not fully reversible, showing sexual development, and the lungs of harmful gases or harmful particles abnormal inflammatory response to the [1]. Oxidation  antioxidant imbalance in the body caused by oxidative stress and inflammation in the lungs have a clear relationship. N  acetyl-cysteine (NAC) was first used in the last century, 60 years, is a classic phlegm drugs. In recent years, as more and more widespread use of clinical and research continued in-depth and found that N  acetylcysteine not only has the mucus dissolution, but also has strong anti-oxidation and promote lung surfactant produce such effects, in the treatment of COPD have a certain effect, this study selected some cases to observe the effect of oxidative stress in elderly patients with COPD and pulmonary function. 1 Data and methods 1.1 General Information 60 cases were in patients with COPD with acute hospital in March 2005 -2007 years, in December outpatient and inpatient services, male 51 cases and 9 females, aged 66 ~ 75 years, mean 70.5 years, duration of 10 ~ 27 years, an average of 15.7Year . All patients are in line with 2002 diagnosis and treatment of chronic obstructive pulmonary disease guidelines for diagnostic criteria [1], 3 months have not used hormones, not accompanied by cardiomyopathy, acute and chronic kidney disease, high blood pressure, liver disease, metabolic diseases, unincorporated asthma, bronchial cancer, tuberculosis and other lung diseases. 1.2 Methods 1.2.1 Grouping and treatment: 60 patients were randomly divided into two groups, treatment grou