Mycoplasma pneumonia activity of humoral immunity.docVIP

 PAGE \* MERGEFORMAT 9 Mycoplasma pneumonia activity of humoral immunity Of: Xu Zhe, CHAN Wah Ying, Liu Yajun, Liu Yan, Wu Xinlian, left Lisa [Abstract] Objective To investigate Mycoplasma pneumoniae pneumonia (Mycoplasma Pneumonia Pneumonia, MPP) serum immunoglobulin (Ig), immune complex (IC) and complement (C) component content and the role in the pathogenesis. Methods Manual Rate nephelometry and turbidimetry polyethylene glycol precipitation and normal control children on the MPP serum IgG, IgA, IgM, IC and complement C1q, C4, C3, B factor levels were detected. results in children with acute MPP and convalescent serum IgG, IgM, IC, C1q, C4, C3, B factors were significantly higher than the control group (P lt;0.01). MPP severe levels of serum IgG, IgA, IC, C1q, C4, C3 contains the most obvious higher than the mild group (P lt;0.01 or lt;0.05). MPP activity of humoral immunity in children with MPP plays an important role in the pathogenesis of the disease to determine the degree of practical value. [Keywords:] Mycoplasma pneumoniae; pneumonia; immunoglobulin; immune complexes; complement Abstract Objective To investigate the changes in component of serum immunoglobulin (Ig), immune complex (IC), complement (C) and its effect in pathogenesis in children with mycoplasma pneumonia (MPP). Methods The levels of serum IgG, IgA, IgM, ICand C1q, C4, C3, B factor were detected in patient with MPP and in normal control group by using turbididity method.Result The levels of serum IgG, IgM, IC and C1q, C4, C3 in severe group were higher than those in mild group (P lt;0.01or lt;0.05). Conclusions The change of activity of homoral immunity was important in pathogenesis of children with MPP and is valuable in determining the severity of disease. KEYWORDS Mycoplasma Pneumonia; Pneumonia; Immunog lobulin; Immune complex; Complement. Mycoplasma pneumoniae (Mycoplasma Pneumonia, MP) is a respiratory tract infection in children common pathogens, but also caused