Neonatal hypoxic-ischemic encephalopathy and its treatment of.doc

 PAGE \* MERGEFORMAT 5 Neonatal hypoxic-ischemic encephalopathy and its treatment of [Keywords:] hypoxic Neonatal hypoxic-ischemic encephalopathy (hypoxic-ischemic encephalopathy, HIE) refers to perinatal hypoxia asphyxia, leading to hypoxic-ischemic brain damage. HIE is not only a serious threat to life and health of newborns, and is an important cause of China’s disabled children. According to statistics, China’s annual live births 1 800 million to 2000 million, the incidence of asphyxia was 13.6% in children with asphyxia occurs in varying degrees of disability were 15.6%, average of over 30 million handicapped children are [1] . Severe asphyxia about 60% to 80% occurred HIE, its mortality and neurological sequelae of about 30% to 40% [2]. In this paper, the pathogenesis and treatment of HIE progress described. 1 Pathogenesis 1.1 hypoxic ischemic brain cell energy metabolism failure and lead to brain damage Neonatal brain tissue metabolism of the most productive, the brain’s oxygen consumption accounts for 50% of whole body oxygen consumption. Brain in hypoxia-ischemia, the cellular oxidative metabolism, this time to rely on anaerobic glycolysis of glucose to generate energy, glycolysis, an increased role for 5 ~ 10 times, a large number of pyruvate is reduced to lactic acid, lactic acid in the brain cells accumulation within the brain cells caused by acidosis and brain edema and rapid development and serious. Hypoxia, brain cells, ATP and creatine phosphate rapidly diminishing, and the lack of cellular energy source, caused by cell membrane ion pump dysfunction, unable to maintain intracellular and extracellular ion difference. K, HPO4-, and Mg2 leakage from the cells, Na, Cl-, Ca2, and H2O into the cell, brain cell swelling, metabolic disorder, resulting in neuronal cell damage, apoptosis and death [3]. 1.2 hypoxic ischemic cerebral vascular dysfunction of self-regulation lead to brain damage Hypoxia-ischemia can cause cerebral edema and stellate ce