Nerve growth factor to promote nerve regeneration research progress.doc

 PAGE \* MERGEFORMAT 16 Nerve growth factor to promote nerve regeneration research progress OF: Viewing on a single, Li Yujia, Tong Xiao-Jie [Abstract] nerve growth factor (nerve growth fact, NGF) was first discovered as a neurotrophic factor, nerve cell growth, differentiation and regeneration play a regulatory role, is involved in nerve regeneration and functional repair damage important factor has attracted the attention of today’s biomedical industry. In this paper, the composition of NGF structure, distribution, biological effects and their relationship with nervous system damage were reviewed. [Keywords:] nerve growth factor; nerve regeneration Abstract: Nerve growth factor (nerve growth factor, NGF) is a kind of earliest discovered nerve nourishment factor, which plays an adjusting role in neuron survival, growth, differentiation and rebirth, and is also an important factor involved in the regeneration and functional repair of the damaged nerve, and has attracted the attention of current biomedical sector. This paper makes a review of the structure, distribution, biological effects of NGF and its relationship with the nervous system injury. Keywords:: nerve growth factor (NGF); nerve regeneration Nerve growth factor 50 in the early 20th century by the Levi-Montalcini in mouse sarcoma cells found in the first neurotrophic factor, is a class of neurons, the target nerve tissue or glial cells can promote the central and peripheral neural differentiation, growth and survival of the activity of proteins, their nervous system development and maintenance of normal physiological function plays an important role. Now, with the nerve on the biological effects of NGF research on the biological effects of non-neuronal cells also has been found: NGF can promote new blood vessel formation, such as for skin flap surgery can increase the blood supply, and the mechanism is that NGF can promote nerve cell Ca2 + to the extracellular release, Ca2 + outflow