Nefopam hydrochloride fentanyl intravenous analgesia for postoperative observation.doc

 PAGE \* MERGEFORMAT 6 Nefopam hydrochloride fentanyl intravenous analgesia for postoperative observation [Abstract] Objective To observe the nefopam hydrochloride, fentanyl for orthopedic surgery-controlled intravenous analgesia analgesic effects and adverse reactions. Methods 30 patients with ASA Ⅰ - Ⅱ grade orthopedic surgery patients were randomly divided into two groups: Ⅰ group, combined with fentanyl hydrochloride, nefopam group (15 cases), Ⅱ group fentanyl group (15 cases). Receiving PCIA treatment. The use of a one-time observation of postoperative analgesia pump 4,8,16,24,48 h of the VAS score and 48h may appear in a response. After the results of the two groups at each time point to compare the analgesic effect was not significantly different (Pamp;gt; 0.05), after 48h the difference in side effects was significant (P amp;lt;0.05), Ⅱ group than in group Ⅰ major side effects. Conclusion nefopam hydrochloride, fentanyl for postoperative PCIA, can reduce the dosage of fentanyl, analgesic effects of satisfaction, adverse reactions is low, can be used as post-operative pain treatment. Nefopam hydrochloride, is a ring of diphenhydramine analogues are widely used in clinical abroad, for moderate and severe pain have a good analgesic effect. Since 2004, we began to fentanyl for postoperative intravenous analgesia (PCIA), has a definite analgesic effects, adverse reactions less features. 1 Materials and Methods 1.1 General Information Select 30 cases no obvious cardiopulmonary disease, ASA Ⅰ - Ⅱ grade orthopedic surgery patients to observe the object, of which five cases of lower limb orthopedic surgery, orthopedic spine surgery in 25 cases, male 26 cases, 4 female, age 21-65 years old, mean (42.6 ± 8.4) years, weight 52-63kg, the average (55.2 ± 11.6) kg. Completion of surgery were randomly divided into two groups: Ⅰ group, combined with fentanyl hydrochloride, nefopam group (15 cases), Ⅱ group fentanyl group (15 cases). 1.2 anesthesia metho