Nasopharyngeal carcinoma using amifostine with concurrent radiotherapy and chemotherapy care.doc

 PAGE \* MERGEFORMAT 12 Nasopharyngeal carcinoma using amifostine with concurrent radiotherapy and chemotherapy care Of: Li Yung-Ching, Tang Zhongmin, Hanzhong Xiu, Huang Wenying, Liang Garden [Abstract] Objective To investigate the side effects of amifostine care. Methods 92 patients with nasopharyngeal carcinoma were randomly divided into two groups to observe 48 patients radiotherapy with concurrent chemotherapy, the use of chemotherapy before the application of amifostine in the control group 44 patients radiotherapy chemotherapy. Results of a study group of 26 cases had decreased blood pressure (54.1%); nausea, vomiting, weight than the control group; serum calcium decreased in 22 cases (45.8%), including 7 cases (14.6%) of the face, hand, foot numbness , convulsions; urinary incontinence in 1 case (2.1%), face, neck and body skin flushing, heat sensation in 2 cases (4.1%), was fatigue, sleepiness in 27 cases (56.2%). Conclusion Amifostine has some side effects, attention to the prevention and timely treatment, intensive care, the patient can tolerate. [Keywords:] Amifostine; side effects; Care Amifostine (amifostine) is a broad cytoprotective drugs [1], which produces the thiol directly with the alkylating agent, platinum combined with chemotherapy drugs or in some activity and the mitigation of toxicity, and clear the radiation therapy (radiotherapy) and oxygen free radicals generated by chemotherapy drugs, selectively protect normal tissue, while no protective effect on tumor tissue. radiotherapy is the preferred treatment of nasopharyngeal carcinoma, cisplatin (DDP) and 5-fluorouracil (5 FU) chemotherapy in NPC first choice, but the renal toxicity of DDP to some extent limit its dosage and efficacy of amifostine can reduce the renal toxicity of DDP [2], but also reduce side effects 5 FU [3], but also have nausea, vomiting, transient hypotension, hypocalcemia and other side effects. We have since July 2009 to December 2009, 48 cases of nasop