Neuroglobin protect the mechanism of nerve cell profiles.doc

 PAGE \* MERGEFORMAT 22 Neuroglobin protect the mechanism of nerve cell profiles [Keywords:] neuroglobin; ischemia and hypoxia; neuroprotective Oxygen is the body’s metabolism and the necessary elements for survival, people have long known that hemoglobin (Hb) and myoglobin (Mb) is the body’s oxygen transport and storage, and removal of mitochondrial oxygen consumption capacity in the process of excess oxygen and other critical material. while the high oxygen consumption of brain tissue, it has been unable to find the nervous system to promote the use of the key molecular oxygen. neuroglobin (Ngb) is a German scientist Burmester T et al [1] first discovered in 2000 in the human and mouse brain tissue, functionally similar to the oxygen-carrying myoglobin myosin. content was low, representing only 0.01% of brain protein of about [1], but with the brain’s oxygen supply is closely related at the molecular level regulating the supply of brain tissue oxygen status of neuroscience research in recent years increasingly become a hot spot. domestic and foreign scholars have done a more in-depth study, now the molecular structure of neuroglobin in the body of the distribution and function, and related research progress in a brief introduction. First, the structure of neuroglobin Neuroglobin in monomeric form, the 151 amino acids, relative molecular weight of 17KD, a small amount of neuroglobin protein polymer, mainly as a dimer, and very few for the tetramer, dimer with disulfide key connected. Ngb under physiological conditions to restore the state of the deoxy form (F8His2 +-E7His) exists, its structure is 6 ligand, human and mouse Ngb is a globin with 6 of them the first monomeric protein ligands [2 ]. Ngb and Hb, Mb are the iron-porphyrin protein, but in the genetic composition and protein structure and other aspects of Hb, Mb are quite different. Ngb genes in higher vertebrates is a highly conserved gene sequences Homology analysis showed that rat and mo