New Development of contrast-enhanced ultrasound.doc

 PAGE \* MERGEFORMAT 9 New Development of contrast-enhanced ultrasound Ultrasound contrast agent is a powder-like substance. As of today, it is in the world in a variety of screening and diagnosis have been with more than 10 million times. Now most of us are using the 20th century, 50’s and 60’s development and improvement of the so-called ‘ionic’ contrast agent. This article describes the ultrasound contrast agents are a class can significantly enhance the diagnosis of ultrasonic testing signal medication, in the human body microcirculation and tissue perfusion test and imaging with ultrasound contrast agents for ultrasonic testing, simple, time-consuming short and real-time non-invasive, no radiation , with other tests such as CT, MRI and other incomparable advantages. Compared with conventional ultrasound imaging, can significantly improve the microcirculation of the diseased tissue perfusion in the level of detection. Therefore, the field of ultrasound contrast enhancement as the most cutting-edge ultrasound cross-disciplinary research focus [1]. 1 Overview 1.1 recognized ultrasound contrast agent (USCAs) began in 1968, Gramiak and Shah reported that injection of indole Fusego green (indocyanine) washed with normal saline or glucose solution to M mode echocardiogram obtained image clearly enhanced. 1.2 ultrasound contrast agent history and development of 1.2.1 The first generation of ultrasound contrast agent with air inclusions, micro-bubbles in the blood vessels within the duration of the decision by the following formula: T = ro2.r/2D * Cs, where ro is the bubble radius, r for the content of gas density, D for the gas dispersion, Cs for gas saturation in the blood. The first generation of the physical characteristics of ultrasound contrast agent to decide its duration is short, easy to break, thus limiting the clinical application of observation and diagnosis time. 1.2.2 The second generation contrast agent’s greatest strength lies in the