New enediyne antitumor antibiotic lidamycin Research Progress.doc

 PAGE \* MERGEFORMAT 32 New enediyne antitumor antibiotic lidamycin Research Progress Keywords: lidamycin;,, enediyne antibiotics;,, anti-tumor Abstract: The structure with enediyne chromophores of antitumor antibiotic Lidamycin on tumor cells have a strong lethal, in recent years found a strong anti-tumor activity of compounds, one of the chemical treatment of the tumor have a good application prospects. This article describes the lidamycin molecular structure and biological synthesis, chemical synthesis, molecular mechanisms and anti-tumor activity of monoclonal antibody conjugate and efficient, combinatorial biosynthesis and other aspects of the study the latest developments. Keywords:: lidamycin; enediyne antibiotics; anti-tumor Advances in the research of lidamycin, an enediyne antitumor antibiotic Ma Di and Hong Bin (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050) ABSTRACT Lidamycin is an enediyne antitumor antibiotic with potent cytotoxicity against varieties of cancer cell lines. It is considered as one of the most effective natural products with antitumor biological activity found in recent years and is expected to have great potential on the chemotherapy of cancers. This article reviews the recent research progress of lidamycin, focusing on its molecular structure, biosynthesis, molecular mechanism of action, antitumor effects, conjugation with monoclonal antibody, as well as the prospective of combinatorial biosynthesis of this class of antibiotics. KEY WORDS Lidamycin; Enediyne antibiotics; Antitumor Lidamycin (lidamycin, LDM) is from China’s Hubei Qianjiang County, isolated from a soil actinomycete Streptomyces globisporus C1027 metabolites were screened out of a new macromolecular antitumor antibiotic protein. Lidamycin contains the chemical structure of enediyne structure of chromophores, is enediyne antibiotics, an import