NF-KB expression in colon cancer and the relationship between_0.doc

 PAGE \* MERGEFORMAT 17 NF-KB expression in colon cancer and the relationship between [Abstract] NF-KB exists in a variety of cells in the body, with many of the genes activated the promoter region of the nucleotide sequence of a fixed combination of gene transcription starts involved in the pathogenesis of many diseases, not only with cell proliferation and ends death, growth and differentiation, cell cycle and state of the body’s immune response, but also with tumor development and metastasis are closely related. Tip NF-KB can be used as a new target for cancer prevention. specifically on the NF-KB inhibition can inhibit tumor development, improve the prognosis. inhibit the transcriptional activity of NF-KB can inhibit colon cancer cell proliferation and promote apoptosis and reversal of resistance to chemotherapeutic drugs to target NF-KB as to explore solutions to the tumor Study of drug resistance has become a new hot spot. In this paper, NF-KB’s role in colon cancer. [Keywords:] NF-KB, cell proliferation, apoptosis, cancer prevention, drug resistance Nuclear factor KB (nuclear factor kappa B, NF-KB) is the first of Sen and Baltimore in nuclear extracts from B lymphocytes were detected with one immunoglobulin κ light chain gene enhancer KB sequence (5’GGGACTITCC3 ‘) specific binding of nuclear protein factor. NF-KB exists in a variety of cells in the body, with many of the genes activated the promoter region of the nucleotide sequence of a fixed combination of gene transcription starts involved in the pathogenesis of many diseases, not only with cell proliferation, apoptosis, growth and differentiation, cell cycle and state of the body’s immune response, but also with tumor development and metastasis are closely related [1-3]. This is on the NF-KB and in colon cancer role reviewed. 1 NF-KB and its inhibitory protein Overview NF-KB is a kind of widespread regulatory function has a number of nuclear transcription factors, can form dimers or he