NFB and ICAM1 in human coronary atherosclerotic plaque expression and disease progression and.doc

 PAGE \* MERGEFORMAT 9 NFB and ICAM1 in human coronary atherosclerotic plaque expression and disease progression and Study: Group Yaowen Jian Wang Bai Zhao Lei Sun Satellite [Abstract] Objective To investigate the inflammatory factor nuclear factor B (NF B), intercellular adhesion molecule 1 (ICAM 1) in the occurrence of coronary atherosclerosis, the role of development and the potential relationship between the two factors. Methods from 55 autopsy cases coronary artery specimens obtained from 55 specimens. using immunohistochemistry to detect NF B, ICAM 1 in each group expressed in the coronary artery. Results normal coronary NF B, ICAM 1 is not expressed in the coronary atherosclerosis plaque block NF B, ICAM 1 expression were increased (P lt;0.05), and both the expression intensity in the endometrium were positively correlated (r = 0.738, P = 0.000). Conclusion NF B, ICAM 1 in coronary artery atherosclerosis occurrence of plaques and evolution. NF B as a key transcription factor induced inflammation may be raised Expression of ICAM 1. [Keywords:] coronary atherosclerotic plaque; nuclear factor B; cell adhesion molecule-1 Atherosclerosis (AS) is endothelial damage due to chronic inflammatory disease (1.) Endothelial injury induced change in endothelial cell surface adhesion, the expression of intercellular adhesion molecule 1 (ICAM 1) and other adhesion molecules, induced by single- nuclear cell adhesion, is initiating the formation of part of AS (2). nuclear factor B (NF B) is a variety of inflammatory and immune responses related to the important transcription factor genes involved in inflammation AS amplification and sustained. past of NF B , ICAM 1 of the research has focused on animal experiments (3), lack of application of human coronary artery specimens of the experimental information. experiment intend to use human specimens of coronary atherosclerosis by immunohistochemistry methods to analyze the event NF B AS , ICAM 1 expression in huma