NFB and open abdominal wound and seawater immersion in rats the relationship between systemic inflammatory response syndrome.doc

 PAGE \* MERGEFORMAT 13 NFB and open abdominal wound and seawater immersion in rats the relationship between systemic inflammatory response syndrome Study: Gang Yu Wang Yuhong Zhang Xi cool plot Yao Li-Jun Zhou Da-Peng Wang Meng Yuhong [Abstract] Objective To investigate the open abdominal wound and seawater immersion in rats with systemic inflammatory response syndrome (SIRS occurs, nuclear factor B (NF B) activity and the relationship between SIRS. Methods open abdominal wound and seawater immersion wound model in rats induced SIRS. enzyme-linked immunosorbent assay (ELISA assay blood tumor necrosis factor-@ (TNF @, interleukin 6 (IL 6 levels, immunohistochemical detection of NF B in peripheral blood lymphocytes (PBL and intestinal tissues of activity. The results open abdominal wound with seawater soak 1 hour, rats had SIRS, blood TNF @, IL 6 levels, immunohistochemistry showed that PBL and intestinal tissues of rats with NF B positive expression was significantly increased compared with the control group statistically significant (P lt;0.05 or P lt;0.01). CONCLUSION open abdominal wound and seawater immersion can be induced SIRS, NF B and cytokines involved in the occurrence of SIRS and development. NF B activation mediates TNF @, IL 6 cytokine release, etc., may be at the center in the SIRS link. [Keywords:] abdominal injuries with seawater immersion of nuclear factor B systemic inflammatory response syndrome Gut in multiple organ dysfunction syndrome (MODS occurred an important role in the development process [1-3], intestinal mucosal barrier dysfunction caused by bacterial translocation and endotoxemia has become a systemic inflammatory response syndrome (SIRS ) is an important incentive, then the start MODS and life-threatening. seawater immersion has the following characteristics: with high blood sodium, high chloride, hyperosmolar state, and severe water and electrolyte disorders, associated with metabolic and respiratory acidosis [4 , 5].