Non-alcoholic fatty liver disease serum protein pattern of clinical research.doc

 PAGE \* MERGEFORMAT 8 Non-alcoholic fatty liver disease serum protein pattern of clinical research [Abstract] of non-alcoholic fatty liver disease in patients with serum protein fingerprinting of non-alcoholic fatty liver disease in patients with differences in protein expression. [Method] The surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI TOF MS and weak cation exchange protein chip (weak cationic exchanger protein chip to detect 29 cases of non-alcoholic fatty liver disease patients and 16 normal healthy human serum, serum protein pattern obtained. [results] in the non-alcoholic fatty liver disease patients and normal control group difference between the 14 proteins detected (P lt;0.05. [Conclusion] The non-alcoholic fatty liver disease and normal healthy people, there are some differences between the expression of proteins. [Keywords:] fatty liver disease, nonalcoholic, protein fingerprinting Non-alcoholic fatty liver disease (NAFLD is a disease in the hepatic lobule of liver steatosis and fat store of the pathological features but no clinical history of excessive alcohol syndrome, including simple fatty liver, steatohepatitis (NASH , fatty liver fibrosis and cirrhosis. In this paper, SELDI TOF MS and protein chip technology from the perspective of the serum protein pattern in NAFLD patients and its significance. 1 Clinical data 29 cases from January 2008 to August 2008, Zhejiang Province People’s Hospital medical staff, in line with the Chinese Medical Association will Hepatology fatty liver and alcoholic liver disease study group in February 2006 revised lt;lt;Non-alcoholic fatty liver disease diagnosis and treatment guidelinesgt; gt; diagnostic criteria specified in [1]. which 27 males and 2 females, aged 27 to 68 years old, average 47.5 years old, elevated serum alanine aminotransferase in 7 cases, -glutamyl GGT increased in 5 cases, (serum alanine aminotransferase and -glutamyl GGT were increased in