NPC Research of multi-drug resistance in.doc

 PAGE \* MERGEFORMAT 27 NPC Research of multi-drug resistance in Abstract cancer multidrug resistance (multidrug resistance, MDR) is the main reason for the failure of chemotherapy to study the phenomenon of MDR mechanisms and resulting ways to overcome the effects of cancer chemotherapy is to enhance one of the main. Full text of the study of MDR status of nasopharyngeal carcinoma were reviewed. 【Key Words】 Nasopharyngeal tumor multidrug resistance Nasopharyngeal carcinoma of southern China and Southeast Asia, one of the most common malignant tumor. In recent years, a large number of clinical studies have shown that radiation therapy combined with chemotherapy can achieve a higher cure rate, simple chemotherapy for advanced nasopharyngeal cancer treatment has been achieved impressive results. However, the overall treatment of nasopharyngeal carcinoma is still unsatisfactory, the majority of patients with advanced chemotherapy ultimately fails due to death, largely due to multidrug resistance in cancer cells (multidrug resistance, MDR). Study produced the phenomenon of MDR mechanisms and ways to overcome the effects of cancer chemotherapy is to enhance one of the main. This article review recent relevant national and international literature on the mechanism of MDR nasopharyngeal carcinoma, MDR and the relationship between radiation, MDR gene expression and the clinical significance of the methods to overcome MDR are summarized below. Produced more than one mechanism of drug resistance 1.1 P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) -Mediated MDR mechanisms P-glycoprotein (P-gp) is a Juliean in 1976 in drug-resistant Chinese hamster ovary cells, was first discovered. This is an energy-dependent membrane transport protein, a molecular weight of 170kDa, encoded by the mdr1 gene. As the P-gp expression and transport function of excessive intake of drugs inside the cell has been transferred