Nose-min water treatment of allergic rhinitis in Rats.doc

 PAGE \* MERGEFORMAT 23 Nose-min water treatment of allergic rhinitis in Rats Author: Huangzhuo Yan, Zhang M, Wei Zi Zhang, Fang Yan-Fei Keywords: allergic rhinitis;,, nose-min water nasal drops Abstract: Objective To investigate the sensitivity of water nasal drops nasal efficacy in treating allergic rhinitis. Ways to ovalbumin sensitized rats the system to do-I allergic animal model, were randomly divided into 3 groups: model control group, the nose-min water group, drug control group, and let the normal control group, the rats were observed behavior of Findings and Determination of histamine content of their nasal mucosa, nasal secretions and serum eosinophils, total serum IgE levels. The results of behavior credits, nose-min after administration of water group, integral behavior of drug control group was significantly lower than model group (P lt;0.01), nose-min water group with lower than the control group of drugs (P lt;0.01); nose-min water group and the control group of drug content in nasal mucosa, nasal secretions of eosinophils was significantly lower than model group (P lt;0.01), nose-min water group and the drug control group there was significant difference (P lt;0.01); nose-min water group and the drug control group, serum eosinophil count, total IgE levels were significantly lower than the model group (P lt;0.01), nose-min water group and the drug control group was not statistically significant (Pgt; 0.05). Conclusion Bimin water nasal drops can reduce histamine content in nasal mucosa in experimental rats, inhibit or reduce the serum total IgE level and eosinophil count, suggesting that sensitivity of water nasal drops for nasal allergic rhinitis have a therapeutic effect. Keywords:: allergic rhinitis; nose-min water nasal drops Experimental Research on the Treatment with BiMinShui on Allergic Rhinitis of Rats Abstract: ObjectiveTo investigate the medical effect of BiMinShui nose drops on the treatment of aller