NOS NO and psoriasis.doc

 PAGE \* MERGEFORMAT 13 NOS NO and psoriasis Keywords:: nitric oxide nitric oxide synthase in psoriatic Of nitric oxide (NO) is a very short half-life may be the proliferation of free radicals, is the partial synthesis of many physiological and pathophysiological function of important biological media. More and more evidence that this simple inorganic molecules in the skin, the adjustment process complex and diverse media to play a paracrine role. NO is a nitric oxide synthase (NOS) under the action comes from the L-arginine-producing. NOS sub-native type (cNOS) and inducible (iNOS). The former sub-neuronal (nNOS, ncNOS, bNOS, NOS1) and endothelial (e NOS, ecNOS, NOS3), is a Ca2 / calmodulin-dependent, and only in the level of intracellular Ca2 increased only when the activity of its NO synthesis short duration (several seconds to several minutes), a low level. In human skin, cNOS pathway to provide a stable and self-regulating function of biological functions, the synthesis of NO is usually played the role of signaling molecules between cells, mediated neurotransmission, regulate blood vessel expansion, melanin formation, and environmental stimuli such as UV-protective reaction . The latter non-Ca2-dependent, the level of transcription regulation, and its activity requires new mRNA and protein synthesis, enzyme activity can maintain a longer time (several hours to several days), may be in a variety of tissues and cells by cytokines and bacterial inside the product of the induced production of NO than the native-type NOS production of up to 1000 times. High levels of NO have non-specific defense function and immune regulation, cell cytotoxicity. NO signal chain, the damage has already been proved and inflammation, hyperplasia, skin cancer and autoimmune skin disease related to. Recently, people have NO plays an important role in human skin, a consensus has been achieved, NO opened a new clinical and molecular study of the leading edge skin [1,2]. NOS, NO in p