Non-syndromic cleft lip and palate susceptibility gene polymorphism progress.doc

 PAGE \* MERGEFORMAT 18 Non-syndromic cleft lip and palate susceptibility gene polymorphism progress [Keywords:] non-syndromic cleft lip and palate susceptibility gene polymorphism in progress Non-syndromic cleft lip with or without cleft palate (nonsyndromic cleft lip with or without cleft palate, NSCL / P; referred to as non-syndromic cleft lip and palate) is not associated with other system malformation syndrome is not affiliated with any lip, cleft lip and cleft palate in general, this is a common congenital deformity of maxillofacial [1]. literatures NSCL / P incidence rate of 1 / 700 [2], the incidence of different ethnic and geographical are very different, in which the yellow race in Asia the highest, followed by European Caucasians, African black people minimum. In our country NSCL / P and high rates of incidence of birth defects in the forefront, much higher than the world average. NSCL / P patients not only cause facial deformities, but also affect the patient’s language, hearing, even affect the mental health of patients, to patients of family and society have brought a serious burden. and NSCL / P in the treatment of joint is a multidisciplinary process, however, most of the NSCL / P cases are not completely cured. So to find the cause of the disease, and find effective means of prevention is very important. That the etiology of NSCL / P is the environmental and genetic interaction. One study suggests that the genetic aspects of NSCL / P is a multi-gene-related diseases, the NSCL / P in the field of gene targeting is a hot and difficult research. Find related candidate gene polymorphisms, and disease association studies of its gene mapping is a common method. With the third generation of single nucleotide polymorphism genetic markers (single nucleotide polymorphism, SNP) discovery, SNP analysis of genes is increasingly being used for gene mapping. SNP genome is a single nucleotide mutation, when the mutation incidence in the population is