NVB and cisplatin after anthracycline chemotherapy in advanced breast cancer.docVIP

 PAGE \* MERGEFORMAT 7 NVB and cisplatin after anthracycline chemotherapy in advanced breast cancer [Keywords:] vinorelbine and cisplatin combination chemotherapy in advanced breast cancer 0 Introduction Combined treatment of chemotherapy in breast cancer occupies a very important position. Anthracycline chemotherapy of breast cancer, one of the main choice has been widely used, but there is still a significant proportion of patients with recurrence and metastasis after treatment for anthracycline chemotherapy in such patients, effective treatment and can choose a generally accepted drug or very important program. We use Vinorelbine (NVB) and cisplatin combined in the treatment of metastatic breast cancer, 32 cases are reported as follows. 1 Materials and Methods 1.1 The object of study in October 2002 ~ July 2004 were treated metastatic breast cancer, 32 cases were female, aged from 31 to 60 years old (median age 47 years), KPS score ≥ 70 points. All patients underwent modified radical mastectomy or radical mastectomy, primary tumors were pathologically confirmed breast cancer, metastatic carcinoma of X-ray, CT or MRI, bone scan confirm the diagnosis. 9 patients with estrogen receptor positive and negative in 19 cases, the receptor is unknown in 4 cases. Pre-menopausal 18 cases, 14 cases of postmenopausal women. Metastatic sites: lung metastasis in 18 cases, liver metastasis in 7 cases, 10 cases of soft tissue metastasis, pleural metastasis, 10 cases of brain metastasis in 3 cases, bone metastasis in 1 case. The individual parts of the transfer of 18 cases, two or more parts of the transfer of 14 cases. All patients were anthracycline treatment failure, of which 20 patients received anthracycline adjuvant chemotherapy in the treatment occur within one year after the transfer of 14 cases of rescue for the anthracycline chemotherapy, disease progression after treatment. 1.2 Treatment of domestic vinorelbine (brand name Gaynor) 25mg/m2 by adding 50ml nor