OAS-1 gene SNP rs2660 spontaneous and chronic HBV infection between HBeAg seroconversion.doc

 PAGE \* MERGEFORMAT 14 OAS-1 gene SNP rs2660 spontaneous and chronic HBV infection between HBeAg seroconversion Of: Chen Biao Lu, Yu Sheng Jie, Xu Town, Xu Qihuan, PENG Xiao seeking, high Zhiliang [Abstract] [Objective] oligo adenylate synthase gene -1 (OAS-1) loci rs2660 single nucleotide polymorphisms (SNP) and chronic hepatitis B virus (HBV) infection spontaneous HBeAg the relationship between seroconversion. [Methods] 126 patients with chronic HBV infection (HBeAg-positive 58 cases, HBeAb positive group 68 patients) and non-HBV infected patients (control group n = 72) of peripheral blood for DNA extraction and amplification, competitive differentiation re-use polymerase chain reaction (CD-PCR) amplification, and chromogenic and enzyme immunoassay to detect the genotype of the SNP between the two groups the proportion of genotype or allele frequency of use? 2 test and advantages of the word ratio (OR) calculations. [Results] In HBeAg-positive group of SNP rs2660 genotype GG + GA ratio of 29.3% (17/58), G allele frequency was 16.4% (19/116), respectively, in the positive group HBeAb 47.1% (32/68) and 28.7% (39/136), the control group were 52.7% (38/72) and 30.6% (44/144); HBeAg-positive group and HBeAb positive group or between the control group There were statistically significant differences (genotype: P = 0.042 and 0.007; allele: P = 0.021 and 0.008), while HBeAb positive group and the control group no significant difference between (genotype: P = 0.499; allele: P = 0.731). [Conclusion] SNP rs2660 G allele of chronic HBV infection may contribute to spontaneous HBeAg seroconversion, the genotypes for interferon treatment of chronic HBV infection may have a certain effect predictive value. [Keywords:] oligo adenylate synthase; single nucleotide polymorphism; hepatitis B virus; allele; genotype Abstract: [Objective] The aim of this study was to investigate the relationship between the single nucleotide polymorphism (SNP) rs2660 of oligoadenylate